Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | MAP2 | P11137 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | SELE | P16581 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21350987 | 0.87 | MCL1 (0.40) | GRM2BRD4ALDH1A1KDM4EHPGD | |
| SCHEMBL21350984 | 0.82 | MAPT (0.50) | CDC7DBF4ALDH1A1KDM4EHPGD | |
| SCHEMBL3555731 | 0.80 | CDC7 (0.46) | MAP2IKBKBCDC7CCNE1CDK2 | |
| SCHEMBL3553404 | 0.76 | CDC7 (0.45) | IKBKBCDC7CCNE1CDK2DBF4 | |
| SCHEMBL22901445 | 0.74 | KDM4E (0.48) | GRM2BRD4IKBKBALDH1A1GAA | |
| SCHEMBL30300679 | 0.71 | CISD2 (0.49) | IKBKBCDC7CCNE1CDK2DBF4 | |
| SCHEMBL3549304 | 0.68 | SRD5A2 (0.45) | ALDH1A1KDM4EHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL12496481 | 0.67 | DAO (0.47) | GRM2ALDH1A1KDM4EGLAHPGD | |
| SCHEMBL30300670 | 0.67 | CISD2 (0.50) | GRM2IKBKBCDC7CCNE1CDK2 | |
| SCHEMBL12496694 | 0.66 | NOTUM (0.36) | BRD4CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3762376-B1 | DIPHENYL SUBSTITUTED THIOPHENE-2-AMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF USEFUL AS ANTIMICROBIAL | DENOVAMED INC (CA) | 2023-03-01 | — | — | EP | disclosed |
| US-11306067-B2 | Diphenyl substituted thiophene-2-amide derivatives and pharmaceutical compositions thereof useful as antimicrobial | DENOVAMED INC. (CA) | 2022-04-19 | — | — | US | disclosed |
| US-20210017147-A1 | Diphenyl Substituted Thiophene-2-Amide Derivatives and Pharmaceutical Compositions Thereof Useful as Antimicrobial | DENOVAMED INC. (CA) | 2021-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11306067-B2 | Diphenyl substituted thiophene-2-amide derivatives and pharmaceutical compositions thereof useful as antimicrobial | MYD88, TPMT, MRPL21 | GRM2 3871/4885BRD4 2329/4885MAP2 1003/4885 |
| US-20210017147-A1 | Diphenyl Substituted Thiophene-2-Amide Derivatives and Pharmaceutical Compositions Thereof Useful as Antimicrobial | MYD88, TPMT, MRPL21 | GRM2 3871/4885BRD4 2329/4885MAP2 1003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.