Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 0.38 |
| ▸ | CA12 | O43570 | 5/20 | 0.38 |
| ▸ | CA1 | P00915 | 5/20 | 0.38 |
| ▸ | CA9 | Q16790 | 5/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | S100A4 | P26447 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25085961 | 0.87 | NOTUM (0.37) | CA2CA12CA1CA9NOTUM | |
| SCHEMBL22901442 | 0.79 | CA1 (0.51) | CA2CA12CA1CA9CA4 | |
| SCHEMBL22901445 | 0.73 | KDM4E (0.48) | NOTUMGRM2CASP3 | |
| SCHEMBL21350986 | 0.73 | GRM2 (0.36) | NOTUMGRM2SCN9AS100A4CASP3 | |
| SCHEMBL12496481 | 0.72 | DAO (0.47) | NOTUMGRM2 | |
| SCHEMBL29719717 | 0.71 | NOTUM (0.53) | NOTUMGRM2S100A4CASP3 | |
| SCHEMBL12496439 | 0.70 | ESR1 (0.37) | NOTUMGRM2SCN9ACASP3 | |
| SCHEMBL21350985 | 0.68 | HDAC6 (0.41) | GRM2 | |
| SCHEMBL12071484 | 0.67 | NOTUM (0.50) | NOTUMGRM2S100A4CASP3 | |
| SCHEMBL21350980 | 0.67 | KDM4E (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3762376-B1 | DIPHENYL SUBSTITUTED THIOPHENE-2-AMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF USEFUL AS ANTIMICROBIAL | DENOVAMED INC (CA) | 2023-03-01 | — | — | EP | disclosed |
| US-11306067-B2 | Diphenyl substituted thiophene-2-amide derivatives and pharmaceutical compositions thereof useful as antimicrobial | DENOVAMED INC. (CA) | 2022-04-19 | — | — | US | disclosed |
| US-20210017147-A1 | Diphenyl Substituted Thiophene-2-Amide Derivatives and Pharmaceutical Compositions Thereof Useful as Antimicrobial | DENOVAMED INC. (CA) | 2021-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11306067-B2 | Diphenyl substituted thiophene-2-amide derivatives and pharmaceutical compositions thereof useful as antimicrobial | MYD88, TPMT, MRPL21 | CA2 4215/4885CA12 4746/4885CA1 4839/4885 |
| US-20210017147-A1 | Diphenyl Substituted Thiophene-2-Amide Derivatives and Pharmaceutical Compositions Thereof Useful as Antimicrobial | MYD88, TPMT, MRPL21 | CA2 4215/4885CA12 4746/4885CA1 4839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.