Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22901548 | 0.92 | MAPT (0.45) | MEN1KMT2AMAPTSMN1; SMN2HTT | |
| SCHEMBL22901549 | 0.83 | MAPT (0.48) | MAPTSMN1; SMN2HTTGCKMAOB | |
| SCHEMBL22901571 | 0.83 | MAPT (0.48) | MEN1KMT2AMAPTSMN1; SMN2HTT | |
| SCHEMBL22901561 | 0.83 | MAOB (0.46) | MEN1KMT2AMAPTSMN1; SMN2HTT | |
| SCHEMBL22901552 | 0.82 | MAPT (0.43) | MEN1KMT2AMAPTSMN1; SMN2HTT | |
| SCHEMBL22901547 | 0.81 | MEN1 (0.51) | MEN1KMT2AMAPTSMN1; SMN2HTT | |
| SCHEMBL22901542 | 0.78 | MAPT (0.47) | MAPTSMN1; SMN2HTTGCKMAOB | |
| SCHEMBL22901565 | 0.78 | MAPT (0.47) | MAPTSMN1; SMN2HTTGCKMAOB | |
| SCHEMBL22901579 | 0.76 | MAPT (0.46) | MAPTSMN1; SMN2HTTGCKMAOB | |
| SCHEMBL22901578 | 0.75 | MAOB (0.48) | MEN1KMT2AMAPTSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021008588-A1 | CLASS OF PYRIMIDINE QUINOLINE DERIVATIVES AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 广州新民培林医药科技有限公司 | 2021-01-21 | — | — | WO | disclosed |