SCHEMBL22902184

SCHEMBL22902184

N#Cc1ccc(-c2cc(=O)[nH]c3c(-c4ccc(Cl)c(Cl)c4)c(C4CC4)nn23)c(OC(=O)[C@@H](N)CCCCN)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
ARF6 P62330 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20796646 0.87 ARF6 (0.78) ARF6
SCHEMBL22902193 0.87 ARF6 (1.00) ARF6
SCHEMBL20796516 0.81 ARF6 (1.00) ARF6
SCHEMBL20796235 0.80 ARF6 (1.00) ARF6
SCHEMBL22902197 0.78 ARF6 (0.84) ARF6
SCHEMBL22902196 0.77 ARF6 (1.00) ARF6
SCHEMBL20796484 0.73 ARF6 (1.00) ARF6
SCHEMBL20796198 0.73 ARF6 (1.00) ARF6
SCHEMBL20796458 0.70 ARF6 (1.00) ARF6
SCHEMBL20796451 0.70 ARF6 (0.83) ARF6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11414442-B2 ARF6 inhibitors and related methods NAVIGEN, INC. (US) 2022-08-16 US disclosed
US-20210017201-A1 ARF6 INHIBITORS AND RELATED METHODS NAVIGEN, INC. 2021-01-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210017201-A1 ARF6 INHIBITORS AND RELATED METHODS ARF6, ARF1, ARF5 ARF6 1/4885
US-11414442-B2 ARF6 inhibitors and related methods ARF6, ARF1, ARF5 ARF6 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.