Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | GABRD | O14764 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14238826 | 0.81 | POLB (0.88) | POLBRECQLALDH1A1HTTCASP3 | |
| SCHEMBL10196666 | 0.79 | POLB (1.00) | POLBRECQLALDH1A1HTTMAPT | |
| SCHEMBL14543129 | 0.79 | POLB (0.94) | POLBRECQLALDH1A1HTTCASP3 | |
| SCHEMBL22904402 | 0.79 | GABRD (0.70) | CHRM2CHRM3GABRDGABRA1GABRB1 | |
| SCHEMBL14238825 | 0.77 | POLB (0.97) | POLBRECQLALDH1A1HTTMAPT | |
| SCHEMBL14238824 | 0.77 | POLB (0.97) | POLBRECQLALDH1A1HTTMAPT | |
| SCHEMBL4548029 | 0.76 | POLB (0.78) | POLBRECQLALDH1A1HTTMAPT | |
| SCHEMBL10196663 | 0.75 | POLB (0.76) | POLBRECQLALDH1A1HTTMAPT | |
| SCHEMBL19710624 | 0.74 | POLB (0.74) | POLBRECQLOPRD1OPRK1ALDH1A1 | |
| SCHEMBL16578039 | 0.74 | POLB (0.74) | POLBRECQLALDH1A1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |