Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRD | O14764 | 3/20 | 0.70 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.70 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.70 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.70 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.70 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.70 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.70 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904422 | 0.81 | GABRD (0.46) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL7130857 | 0.80 | HPGD (0.83) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL14238822 | 0.80 | HPGD (0.83) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL17244442 | 0.79 | HPGD (0.68) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL22904094 | 0.79 | TSHR (0.57) | HPGDHTTMGLL | |
| SCHEMBL22904091 | 0.79 | POLB (0.64) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL2667152 | 0.77 | HPGD (0.90) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL1753626 | 0.77 | HPGD (0.97) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL22904090 | 0.76 | GABRD (0.50) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL14538230 | 0.76 | HPGD (0.71) | GABRDGABRA1GABRB1GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |