Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 3/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | PRKCB | P05771 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904357 | 0.90 | DDB1 (0.44) | DDB1CRBNDRD2NAMPTCAMK2D | |
| SCHEMBL22904570 | 0.89 | DDB1 (0.43) | DDB1CRBNDRD2CAMK2DPDPK1 | |
| SCHEMBL22904572 | 0.89 | DDB1 (0.43) | DDB1CRBNDRD2CAMK2DPDPK1 | |
| SCHEMBL22904100 | 0.85 | DDB1 (0.52) | DDB1CRBNDRD2PTPN11TDP2 | |
| SCHEMBL22904360 | 0.78 | DRD2 (0.46) | DRD2NAMPTPDPK1CCNB2PRKCB | |
| SCHEMBL22904571 | 0.78 | DRD2 (0.46) | DRD2NAMPTPDPK1CCNB2PRKCB | |
| SCHEMBL22904569 | 0.78 | DRD2 (0.46) | DRD2NAMPTPDPK1CCNB2PRKCB | |
| SCHEMBL22904408 | 0.77 | DRD2 (0.42) | DDB1CRBNDRD2PTPN11 | |
| SCHEMBL22904367 | 0.77 | BRD4 (0.45) | DDB1CRBNDRD2TDP2NAMPT | |
| SCHEMBL22904406 | 0.75 | DRD2 (0.43) | DRD2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |