Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 2/20 | 0.52 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.52 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.35 |
| ▸ | HAO1 | Q9UJM8 | 6/20 | 0.34 |
| ▸ | TDP2 | O95551 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904102 | 0.91 | DDB1 (0.43) | DDB1CRBNDRD2HAO1PARP1 | |
| SCHEMBL22904410 | 0.89 | DDB1 (0.42) | DDB1CRBNDRD2 | |
| SCHEMBL22904412 | 0.89 | DDB1 (0.42) | DDB1CRBNDRD2 | |
| SCHEMBL22904364 | 0.85 | DDB1 (0.51) | DDB1CRBNPTPN11DRD2TDP2 | |
| SCHEMBL22904367 | 0.84 | BRD4 (0.45) | DDB1CRBNDRD2TDP2BRD4 | |
| SCHEMBL22904408 | 0.82 | DRD2 (0.42) | DDB1CRBNPTPN11DRD2 | |
| SCHEMBL22904409 | 0.81 | DRD2 (0.41) | DDB1CRBNPTPN11DRD2 | |
| SCHEMBL22904101 | 0.81 | DRD2 (0.42) | DRD2 | |
| SCHEMBL22904496 | 0.80 | TDP2 (0.40) | HAO1TDP2ALOX5 | |
| SCHEMBL22904413 | 0.79 | DRD2 (0.41) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |