Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 9/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27097204 | 0.88 | KHK (0.42) | KHKKDM4EALK | |
| SCHEMBL22906920 | 0.85 | CHKA (0.38) | KHKALDH1A1MAPTPKM | |
| SCHEMBL27097283 | 0.85 | KHK (0.36) | KHKKDM4EALDH1A1CDK4CYP3A4 | |
| SCHEMBL27097206 | 0.84 | MAPT (0.39) | KHKMAPTPKMCDK4TSHR | |
| SCHEMBL22906925 | 0.83 | ADRB2 (0.43) | KHKALDH1A1CDK4 | |
| SCHEMBL27097281 | 0.81 | KHK (0.33) | KHKMAPTCDK4CYP3A4 | |
| SCHEMBL22906822 | 0.76 | CDK4 (0.39) | KHKCDK4 | |
| SCHEMBL22906574 | 0.74 | ACHE (0.40) | MAPTCYP2D6EGFR | |
| SCHEMBL29773834 | 0.72 | CHUK (0.36) | CYP2D6EGFRALK | |
| SCHEMBL22907358 | 0.72 | CHUK (0.36) | CYP2D6EGFRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011913-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |