Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | CKS1B | P61024 | 2/20 | 0.49 |
| ▸ | SKP1 | P63208 | 2/20 | 0.49 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22907253 | 0.88 | MAP4K4 (0.53) | MAP4K4CKS1BSKP1SKP2MAPT | |
| SCHEMBL12328836 | 0.83 | MAP4K4 (0.57) | MAP4K4CKS1BSKP1SKP2MAPT | |
| SCHEMBL30686573 | 0.82 | MAP4K4 (0.37) | MAP4K4CKS1BSKP1SKP2MAPT | |
| SCHEMBL20046669 | 0.82 | CKS1B (0.58) | MAP4K4CKS1BSKP1SKP2MAPT | |
| SCHEMBL2448474 | 0.81 | MAP4K4 (0.56) | MAP4K4CKS1BSKP1SKP2MAPT | |
| SCHEMBL31130022 | 0.81 | MAP4K4 (0.65) | MAP4K4CKS1BSKP1SKP2MAPT | |
| SCHEMBL31129803 | 0.80 | ALDH1A1 (0.57) | MAP4K4CKS1BSKP1SKP2MAPT | |
| SCHEMBL20163032 | 0.80 | CKS1B (0.56) | MAP4K4CKS1BSKP1SKP2MAPT | |
| SCHEMBL3186820 | 0.80 | CKS1B (0.56) | MAP4K4CKS1BSKP1SKP2MAPT | |
| SCHEMBL16333807 | 0.80 | MAP4K4 (0.52) | MAP4K4CKS1BSKP1SKP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011913-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |