Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | CKS1B | P61024 | 2/20 | 0.52 |
| ▸ | SKP1 | P63208 | 2/20 | 0.52 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31130022 | 0.87 | MAP4K4 (0.65) | MAP4K4CKS1BSKP1SKP2GPR119 | |
| SCHEMBL12328836 | 0.86 | MAP4K4 (0.57) | MAP4K4CKS1BSKP1SKP2GPR119 | |
| SCHEMBL17310233 | 0.85 | MAP4K4 (0.54) | MAP4K4CKS1BSKP1SKP2GPR119 | |
| SCHEMBL22118550 | 0.85 | MAP4K4 (0.56) | MAP4K4CKS1BSKP1SKP2GPR119 | |
| SCHEMBL29435004 | 0.85 | MAP4K4 (0.56) | MAP4K4CKS1BSKP1SKP2GPR119 | |
| SCHEMBL22907259 | 0.81 | MAP4K4 (0.53) | MAP4K4CKS1BSKP1SKP2GPR119 | |
| SCHEMBL27027530 | 0.81 | MAP4K4 (0.55) | MAP4K4CKS1BSKP1SKP2GPR119 | |
| SCHEMBL15173541 | 0.81 | MAP4K4 (0.64) | MAP4K4CKS1BSKP1SKP2GPR119 | |
| SCHEMBL461584 | 0.81 | CKS1B (0.62) | MAP4K4CKS1BSKP1SKP2GPR119 | |
| SCHEMBL31129803 | 0.81 | ALDH1A1 (0.57) | MAP4K4CKS1BSKP1SKP2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9108937-B2 | Positive allosteric modulators of mGluR2 | MERCK SHARP & DOHME CORP. (US) | 2015-08-18 | — | — | US | disclosed |
| US-9108937-B2 | Positive allosteric modulators of mGluR2 | MERCK SHARP & DOHME CORP. (US) | 2015-08-18 | — | — | US | disclosed |
| US-9108937-B2 | Positive allosteric modulators of mGluR2 | MERCK SHARP & DOHME CORP. (US) | 2015-08-18 | — | — | US | disclosed |
| EP-2542083-B1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME (US) | 2015-05-06 | — | — | EP | disclosed |
| EP-2542083-B1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME (US) | 2015-05-06 | — | — | EP | disclosed |
| US-20130158002-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME LLC | 2013-06-20 | — | — | US | disclosed |
| US-20130158002-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME LLC | 2013-06-20 | — | — | US | disclosed |
| US-20130158002-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME LLC | 2013-06-20 | — | — | US | disclosed |
| EP-2542083-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | Merck Sharp & Dohme Corp. (US) | 2013-01-09 | — | — | EP | disclosed |
| WO-2011109277-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2011-09-09 | — | — | WO | disclosed |
| WO-2011109277-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2011-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158002-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | GRM2, GRM1, GRM3 | MAP4K4 2290/4885CKS1B 2484/4885SKP1 3414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.