Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.66 |
| ▸ | ACHE | P22303 | 4/20 | 0.49 |
| ▸ | MIF | P14174 | 3/20 | 0.48 |
| ▸ | CES2 | O00748 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25499549 | 0.82 | METAP1 (0.70) | METAP1ACHEMIFALDH1A1GAA | |
| SCHEMBL1512575 | 0.82 | METAP1 (0.70) | METAP1ACHEMIFCES2ABCB1 | |
| SCHEMBL10267899 | 0.79 | METAP1 (1.00) | METAP1ACHEMIFCES2ABCB1 | |
| SCHEMBL10693161 | 0.78 | METAP1 (0.64) | METAP1ACHEMIFCES2ABCB1 | |
| SCHEMBL10623445 | 0.78 | ALDH1A1 (0.64) | METAP1ACHEALDH1A1GAAHPGD | |
| SCHEMBL4895916 | 0.77 | METAP1 (0.61) | METAP1ACHEALDH1A1GAAHPGD | |
| SCHEMBL27456260 | 0.77 | METAP1 (0.62) | METAP1ACHEALDH1A1GAAKDM4E | |
| SCHEMBL23835146 | 0.76 | METAP1 (0.73) | METAP1ACHEMIFABCB1ALDH1A1 | |
| SCHEMBL30887372 | 0.76 | METAP1 (0.73) | METAP1ACHEMIFABCB1ALDH1A1 | |
| SCHEMBL4808970 | 0.76 | MIF (0.61) | METAP1ACHEMIFCES2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011913-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |