SCHEMBL2290737

SCHEMBL2290737

Cc1cc(C)nc(C(=O)c2cccc(Cl)c2N)n1

nearest known ligand 0.48

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.48
KDM4E B2RXH2 3/20 0.48
POLB P06746 1/20 0.48
NR4A2 P43354 1/20 0.43
CD38 P28907 5/20 0.42
CYP3A4 P08684 3/20 0.42
LMNA P02545 3/20 0.41
HSP90AA1 P07900 1/20 0.41
GAA P10253 1/20 0.41
RECQL P46063 1/20 0.40
TP53 P04637 1/20 0.39
MAPT P10636 2/20 0.39
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2283859 0.88 NPSR1 (0.44) ALDH1A1KDM4EPOLBCD38CYP3A4
SCHEMBL2289383 0.84 NPSR1 (0.47) ALDH1A1KDM4EPOLBLMNAHSP90AA1
SCHEMBL2281968 0.81 MITF (0.44) ALDH1A1KDM4EPOLBCD38CYP3A4
SCHEMBL2292177 0.81 F2 (0.40) ALDH1A1KDM4EPOLBLMNAHSP90AA1
SCHEMBL15608485 0.76 POLB (0.44) ALDH1A1KDM4EPOLBLMNAGAA
SCHEMBL15608370 0.76 MAPK14 (0.50) ALDH1A1CYP3A4LMNAGAARECQL
SCHEMBL15608527 0.75 POLB (0.58) ALDH1A1KDM4EPOLBLMNAMAPT
SCHEMBL11967601 0.75 NPSR1 (0.40) ALDH1A1KDM4ELMNAGAA
SCHEMBL11320349 0.74 AKR1C3 (0.53) ALDH1A1LMNAGAAMAPTKMT2A
SCHEMBL15608444 0.74 ALDH1A1 (0.56) ALDH1A1KDM4EPOLBLMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1773124-B1 A USE OF SULFONANILIDES AS AGRICULTURAL AND HORTICULTURAL FUNGICIDE BAYER CROPSCIENCE AG (DE) 2012-08-22 EP disclosed
US-8008484-B2 Use of sulfonanilides as agricultural and horticultural fungicide BAYER CROPSCIENCE AG (DE) 2011-08-30 US disclosed
US-20070219199-A1 Use of Sulfonanilides as Agricultural and Horticultural Fungicide BAYER CROPSCIENCE AG (DE) 2007-09-20 US disclosed
EP-1773124-A1 A USE OF SULFONANILIDES AS AGRICULTURAL AND HORTICULTURAL FUNGICIDE Bayer CropScience Aktiengesellschaft (DE) 2007-04-18 EP disclosed
WO-2006008159-A1 A USE OF SULFONANILIDES AS AGRICULTURAL AND HORTICULTURAL FUNGICIDE BAYER CROPSCIENCE AG (DE) 2006-01-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070219199-A1 Use of Sulfonanilides as Agricultural and Horticultural Fungicide CBR3, CYP51A1, CBR1 ALDH1A1 1037/4885KDM4E 1374/4885POLB 4783/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.