Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 8/20 | 0.57 |
| ▸ | PDCD1 | Q15116 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8421355 | 0.90 | GAA (0.55) | CD274PDCD1KMT2AMAPTMEN1 | |
| SCHEMBL22908674 | 0.84 | KMT2A (0.70) | CD274PDCD1KMT2AMAPTMEN1 | |
| SCHEMBL4013719 | 0.78 | KMT2A (0.42) | CD274PDCD1KMT2AMAPTMEN1 | |
| SCHEMBL11727835 | 0.77 | CD274 (0.66) | CD274PDCD1KMT2AMAPTMEN1 | |
| SCHEMBL7707656 | 0.76 | ALDH1A1 (0.55) | CD274PDCD1KMT2AMAPTMEN1 | |
| SCHEMBL10435326 | 0.75 | MAPT (0.75) | CD274PDCD1KMT2AMAPTMEN1 | |
| SCHEMBL5457017 | 0.75 | CD274 (0.56) | CD274PDCD1KMT2AMAPTMEN1 | |
| SCHEMBL5461278 | 0.75 | CD274 (0.49) | CD274PDCD1KMT2AMAPTMEN1 | |
| SCHEMBL1110494 | 0.74 | MAPT (0.58) | CD274PDCD1KMT2AMAPTMEN1 | |
| SCHEMBL5461639 | 0.74 | MAPT (0.58) | CD274PDCD1KMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021009384-A1 | NOVEL PYRAZOLONE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS | CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE (FR) | 2021-01-21 | — | — | WO | disclosed |