Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL417693 | 0.84 | LTA4H (0.55) | LTA4HSLC6A4SLC6A3SLC6A2FFAR1 | |
| SCHEMBL22910532 | 0.84 | LTA4H (0.47) | ALDH1A1PKMLTA4HSLC6A4HTR2A | |
| SCHEMBL8281063 | 0.83 | LTA4H (0.50) | LTA4HSLC6A4HTR2ASLC6A3SLC6A2 | |
| SCHEMBL22910528 | 0.81 | SLC6A4 (0.47) | ALDH1A1PKMLTA4HSLC6A4HTR2A | |
| SCHEMBL22910540 | 0.81 | LTA4H (0.45) | ALDH1A1PKMLTA4HSLC6A4HTR2A | |
| SCHEMBL23330219 | 0.81 | BCHE (0.41) | ALDH1A1SLC6A4SLC6A3LIPGPTGS2 | |
| SCHEMBL4417329 | 0.81 | SLC6A4 (0.57) | LTA4HSLC6A4HTR2ASLC6A3SLC6A2 | |
| SCHEMBL23229977 | 0.79 | DPP4 (0.48) | ALDH1A1PKMLTA4HSLC6A4SLC6A3 | |
| SCHEMBL29655939 | 0.79 | PTGS2 (0.52) | ALDH1A1SLC6A4SLC6A3PTGS2KCNH2 | |
| SCHEMBL12806496 | 0.79 | PTGS2 (0.52) | ALDH1A1SLC6A4SLC6A3PTGS2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021072203-A1 | TGFBETAR1 INHIBITOR-ASGR ANTIBODY CONJUGATES AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021011834-A1 | ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |