Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 11/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16759875 | 1.00 | IDH1 (0.41) | IDH1KDM4EHSD11B1ALDH1A1ATXN2 | |
| SCHEMBL22910765 | 0.89 | IDH1 (0.39) | IDH1KDM4EHSD11B1ALDH1A1 | |
| SCHEMBL18082352 | 0.86 | KDM4E (0.36) | IDH1KDM4EHSD11B1ALDH1A1 | |
| SCHEMBL22910820 | 0.86 | KDM4E (0.36) | IDH1KDM4EHSD11B1ALDH1A1 | |
| SCHEMBL22910866 | 0.83 | PDE2A (0.39) | IDH1KDM4EHSD11B1ALDH1A1ATXN2 | |
| SCHEMBL16759830 | 0.83 | PDE2A (0.39) | IDH1KDM4EHSD11B1ALDH1A1ATXN2 | |
| SCHEMBL16759849 | 0.83 | PDK2 (0.33) | IDH1KDM4EHSD11B1 | |
| SCHEMBL22910833 | 0.83 | PDK2 (0.33) | IDH1KDM4EHSD11B1 | |
| SCHEMBL22911084 | 0.79 | LMNA (0.39) | KDM4EHSD11B1ALDH1A1 | |
| SCHEMBL16759810 | 0.79 | LMNA (0.39) | KDM4EHSD11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210015792-A1 | OCTAHYDRO-CYCLOBUTA[1,2-c;3,4-c']DIPYRROL-2-YL | HOFFMANN-LA ROCHE INC. (US) | 2021-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210015792-A1 | OCTAHYDRO-CYCLOBUTA[1,2-c;3,4-c']DIPYRROL-2-YL | NPY1R, NPY2R, DECR1 | IDH1 1323/4885KDM4E 1536/4885HSD11B1 345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.