Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 13/20 | 0.44 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19411404 | 0.84 | SCN9A (0.51) | SCN9ASCN7ASCN5A | |
| SCHEMBL19411383 | 0.84 | SCN9A (0.51) | SCN9AKCNH2MRGPRX4 | |
| SCHEMBL19429991 | 0.83 | SCN9A (0.63) | SCN9AKCNH2MRGPRX4 | |
| SCHEMBL19411409 | 0.79 | SCN9A (0.46) | SCN9ASCN7ASCN5AKCNH2MRGPRX4 | |
| SCHEMBL23677194 | 0.78 | SCN9A (0.44) | SCN9ASCN7ASCN5AKCNH2MRGPRX4 | |
| SCHEMBL16239866 | 0.70 | SCN9A (0.60) | SCN9ASCN5A | |
| SCHEMBL23677149 | 0.68 | SCN9A (0.38) | SCN9AKCNH2MRGPRX4 | |
| SCHEMBL19411391 | 0.64 | SCN9A (0.73) | SCN9ASCN7ASCN5A | |
| SCHEMBL17423019 | 0.63 | SCN9A (0.82) | SCN9ASCN7ASCN5A | |
| SCHEMBL15543308 | 0.62 | SCN9A (0.80) | SCN9ASCN7ASCN5AMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436432-B1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2021-01-27 | — | — | EP | disclosed |