Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23677194 | 0.90 | SCN9A (0.44) | SCN9AKCNH2XDHPTGDR2MRGPRX4 | |
| SCHEMBL19411383 | 0.73 | SCN9A (0.51) | SCN9AKCNH2XDHPTGDR2MRGPRX4 | |
| SCHEMBL19429991 | 0.72 | SCN9A (0.63) | SCN9AKCNH2XDHPTGDR2AOC3 | |
| SCHEMBL23677150 | 0.71 | SCN9A (0.46) | SCN9AKCNH2NPC1RAB9AHPGD | |
| SCHEMBL19411409 | 0.71 | SCN9A (0.46) | SCN9AKCNH2XDHPTGDR2MRGPRX4 | |
| SCHEMBL19411404 | 0.69 | SCN9A (0.51) | SCN9A | |
| SCHEMBL22912670 | 0.68 | SCN9A (0.44) | SCN9AKCNH2MRGPRX4 | |
| SCHEMBL23677146 | 0.68 | SCN9A (0.67) | SCN9A | |
| SCHEMBL12326824 | 0.61 | DRD4 (0.42) | PTGDR2ALDH1A1HPGD | |
| SCHEMBL19429995 | 0.60 | SCN9A (0.67) | SCN9AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3854782-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2021-07-28 | — | — | EP | disclosed |