Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24409525 | 0.88 | CNR1 (0.39) | CNR1CNR2PDE5APTGER4PIK3R1 | |
| SCHEMBL22912886 | 0.84 | CNR1 (0.44) | CNR1CNR2PDE5AMAPTPTGER4 | |
| SCHEMBL22913399 | 0.83 | SLC22A12 (0.49) | MAPTPTGER4AKR1C3 | |
| SCHEMBL24484019 | 0.81 | CNR1 (0.45) | CNR1CNR2PDE5AMAPTPIK3R1 | |
| SCHEMBL16014218 | 0.81 | CNR1 (0.45) | CNR1CNR2PDE5AMAPTPIK3R1 | |
| SCHEMBL29670185 | 0.81 | CNR1 (0.45) | CNR1CNR2PDE5AMAPTPIK3R1 | |
| SCHEMBL5103746 | 0.81 | CNR1 (0.44) | CNR1CNR2PDE5AMAPTPTGER4 | |
| SCHEMBL29071996 | 0.80 | PIK3R1 (0.46) | PDE5AMAPTPIK3R1PIK3CAMEN1 | |
| SCHEMBL22912889 | 0.79 | CNR1 (0.43) | CNR1CNR2PDE5APTGER4PIK3R1 | |
| SCHEMBL24148851 | 0.78 | CNR1 (0.45) | CNR1CNR2MAPTPTGER4PIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114929683-B | Pyridine derivatives as modulators of calcium activated chloride channels | 跨膜蛋白16A有限公司 | 2024-09-03 | — | — | CN | disclosed |
| US-20220144803-A1 | PYRIDINE DERIVATIVES AS CALCIUM-ACTIVATED CHLORIDE CHANNEL MODULATORS | Enterprise Therapeutics Limited (GB) | 2022-05-12 | — | — | US | disclosed |
| WO-2021014172-A1 | PYRIDINE DERIVATIVES AS CALCIUM-ACTIVATED CHLORIDE CHANNEL MODULATORS | Enterprise Therapeutics Limited (GB) | 2021-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220144803-A1 | PYRIDINE DERIVATIVES AS CALCIUM-ACTIVATED CHLORIDE CHANNEL MODULATORS | TMEM109, CACNA1E, CACNA1A | CNR1 355/4885CNR2 496/4885PDE5A 1452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.