Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.40 |
| ▸ | CASR | P41180 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 2/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29703944 | 0.93 | PIK3R1 (0.46) | PIK3R1PIK3CAMAPK8PDE1BP2RX4 | |
| SCHEMBL29393141 | 0.85 | DCTPP1 (0.42) | PIK3R1PIK3CAPDE1BP2RX4MAPT | |
| SCHEMBL13178171 | 0.81 | CCR2 (0.49) | PIK3R1PIK3CAP2RX4MAPTKMT2A | |
| SCHEMBL22912862 | 0.80 | CNR1 (0.43) | PIK3R1PIK3CAMAPK8MAPTKMT2A | |
| SCHEMBL19896458 | 0.78 | P2RX4 (0.52) | PIK3R1PIK3CAMAPK8PDE1BP2RX4 | |
| SCHEMBL31283391 | 0.78 | PDE1B (0.40) | PIK3R1PIK3CAPDE1BP2RX4MAPT | |
| SCHEMBL24307080 | 0.73 | PDE5A (0.65) | PIK3R1PIK3CAMAPK8PDE1BP2RX4 | |
| SCHEMBL31042159 | 0.73 | PDE5A (0.65) | PIK3R1PIK3CAMAPK8PDE1BP2RX4 | |
| SCHEMBL7409652 | 0.72 | DYRK1A (0.54) | MAPTP2RX3 | |
| SCHEMBL23723081 | 0.71 | PDE1B (0.61) | PIK3R1PIK3CAPDE1BP2RX4DCTPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116745269-A | Dihydroquinazolin-2-one derivatives as selective cytotoxic agents for the treatment of HIV | 默沙东有限责任公司 | 2023-09-12 | — | — | CN | disclosed |
| EP-4204413-A1 | DIHYDROQUINAZOLIN-2-ONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS USEFUL IN THE TREATMENT OF HIV | Merck Sharp & Dohme LLC (US) | 2023-07-05 | — | — | EP | disclosed |
| WO-2022125412-A1 | TETRAHYDROQUINAZOLINE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-16 | — | — | WO | disclosed |
| WO-2022046844-A1 | DIHYDROQUINAZOLIN-2-ONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS USEFUL IN THE TREATMENT OF HIV | MERCK SHARP & DOHME CORP. (US) | 2022-03-03 | — | — | WO | disclosed |