Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | GRK2 | P25098 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15327068 | 0.83 | KDM4E (0.47) | EGLN1ROCK2GRK2LMNAMAPK1 | |
| SCHEMBL2227256 | 0.81 | MAPT (0.67) | ROCK2GRK2LMNAMAPK1MAPT | |
| SCHEMBL2202613 | 0.79 | EGLN1 (0.65) | EGLN1ROCK2GRK2LMNAMAPK1 | |
| SCHEMBL18215350 | 0.72 | MAPK1 (0.56) | LMNAMAPK1MAPTHDAC6HDAC3 | |
| SCHEMBL16435281 | 0.72 | ROCK2 (0.54) | ROCK2GRK2LMNAMAPK1MAPT | |
| SCHEMBL3362629 | 0.72 | HDAC6 (0.65) | EGLN1HDAC6HDAC3HDAC8HDAC1 | |
| SCHEMBL12361022 | 0.71 | MMP13 (0.59) | EGLN1ROCK2LMNAMAPK1NAMPT | |
| SCHEMBL22753445 | 0.70 | MAPK1 (0.57) | LMNAMAPK1MAPTHDAC6HDAC3 | |
| SCHEMBL17941874 | 0.70 | EGLN1 (0.62) | EGLN1HDAC6HDAC3HDAC1KDM4E | |
| SCHEMBL2283028 | 0.70 | HDAC6 (0.66) | ROCK2GRK2LMNAMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519504-A1 | NEW SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES. | Polichem SA (LU) | 2012-11-07 | — | — | EP | claimed |
| WO-2011080266-A1 | NEW SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES. | POLICHEM S.A. (LU) | 2011-07-07 | — | — | WO | claimed |