Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22915211 | 0.89 | TP53 (0.42) | TP53MAPTGAACHEK1STK10 | |
| SCHEMBL22915127 | 0.85 | TP53 (0.43) | TP53MAPTCHEK1ALDH1A1LMNA | |
| SCHEMBL22915137 | 0.84 | TP53 (0.52) | TP53GAAALDH1A1LMNANPSR1 | |
| SCHEMBL22915160 | 0.84 | TP53 (0.52) | TP53GAAALDH1A1LMNANPSR1 | |
| SCHEMBL22915219 | 0.84 | LMNA (0.50) | TP53MAPTALDH1A1LMNANPSR1 | |
| SCHEMBL22915162 | 0.83 | TP53 (0.49) | TP53MAPTCHEK1ALDH1A1LMNA | |
| SCHEMBL22915151 | 0.83 | TP53 (0.52) | TP53MAPTCHEK1ALDH1A1LMNA | |
| SCHEMBL22915193 | 0.80 | TP53 (0.43) | TP53MAPTALDH1A1LMNANPSR1 | |
| SCHEMBL22915150 | 0.78 | TP53 (0.43) | TP53MAPTALDH1A1LMNANPSR1 | |
| SCHEMBL22915173 | 0.77 | TP53 (0.43) | TP53MAPTGAAALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11440892-B2 | Substituted dihydrobenzoxazinones, dihydroquinolones, and methods of their use and synthesis | NORTHWESTERN UNIVERSITY (US) | 2022-09-13 | — | — | US | disclosed |
| US-20210024473-A1 | SUBSTITUTED DIHYDROBENZOXAZINONES, DIHYDROQUINOLONES, AND METHODS OF THEIR USE AND SYNTHESIS | NORTHWESTERN UNIVESITY | 2021-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210024473-A1 | SUBSTITUTED DIHYDROBENZOXAZINONES, DIHYDROQUINOLONES, AND METHODS OF THEIR USE AND SYNTHESIS | NQO1, DHPS, NQO2 | TP53 2011/4885MAPT 3887/4885GAA 367/4885 |
| US-11440892-B2 | Substituted dihydrobenzoxazinones, dihydroquinolones, and methods of their use and synthesis | NQO1, DHPS, NQO2 | TP53 2011/4885MAPT 3887/4885GAA 367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.