Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.36 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22915137 | 0.88 | TP53 (0.52) | ALDH1A1LMNATDP1TP53HTT | |
| SCHEMBL22915160 | 0.88 | TP53 (0.52) | ALDH1A1LMNATDP1TP53HTT | |
| SCHEMBL22915150 | 0.87 | TP53 (0.43) | ALDH1A1LMNATDP1TP53HTT | |
| SCHEMBL22915127 | 0.86 | TP53 (0.43) | ALDH1A1LMNATDP1TP53HTT | |
| SCHEMBL22915173 | 0.86 | TP53 (0.43) | ALDH1A1LMNATDP1TP53HTT | |
| SCHEMBL22915219 | 0.85 | LMNA (0.50) | ALDH1A1LMNATDP1TP53HTT | |
| SCHEMBL22915165 | 0.85 | TP53 (0.60) | ALDH1A1LMNATDP1TP53NPSR1 | |
| SCHEMBL22915143 | 0.83 | TP53 (0.55) | ALDH1A1LMNATDP1TP53NPSR1 | |
| SCHEMBL22915121 | 0.83 | TP53 (0.52) | ALDH1A1LMNATDP1TP53HTT | |
| SCHEMBL22915193 | 0.80 | TP53 (0.43) | ALDH1A1LMNATDP1TP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11440892-B2 | Substituted dihydrobenzoxazinones, dihydroquinolones, and methods of their use and synthesis | NORTHWESTERN UNIVERSITY (US) | 2022-09-13 | — | — | US | disclosed |
| US-20210024473-A1 | SUBSTITUTED DIHYDROBENZOXAZINONES, DIHYDROQUINOLONES, AND METHODS OF THEIR USE AND SYNTHESIS | NORTHWESTERN UNIVESITY | 2021-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210024473-A1 | SUBSTITUTED DIHYDROBENZOXAZINONES, DIHYDROQUINOLONES, AND METHODS OF THEIR USE AND SYNTHESIS | NQO1, DHPS, NQO2 | ALDH1A1 633/4885LMNA 1464/4885TDP1 2088/4885 |
| US-11440892-B2 | Substituted dihydrobenzoxazinones, dihydroquinolones, and methods of their use and synthesis | NQO1, DHPS, NQO2 | ALDH1A1 633/4885LMNA 1464/4885TDP1 2088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.