Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 9/20 | 0.68 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.66 |
| ▸ | ESR1 | P03372 | 5/20 | 0.61 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | SHBG | P04278 | 2/20 | 0.61 |
| ▸ | PGR | P06401 | 2/20 | 0.61 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.61 |
| ▸ | AR | P10275 | 2/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.61 |
| ▸ | SNCA | P37840 | 2/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | STS | P08842 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.61 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12379386 | 1.00 | HSD17B1 (0.68) | HSD17B1AKR1C3ESR1ESR2LMNA | |
| SCHEMBL2290673 | 0.88 | HSD17B1 (0.69) | HSD17B1AKR1C3ESR1ESR2LMNA | |
| SCHEMBL12379452 | 0.88 | HSD17B1 (0.69) | HSD17B1AKR1C3ESR1ESR2LMNA | |
| SCHEMBL12418958 | 0.85 | HSD17B1 (0.82) | HSD17B1AKR1C3ESR1ESR2LMNA | |
| SCHEMBL12379440 | 0.85 | MAPT (0.63) | HSD17B1AKR1C3LMNACYP3A4STS | |
| SCHEMBL2292483 | 0.85 | MAPT (0.63) | HSD17B1AKR1C3LMNACYP3A4STS | |
| SCHEMBL1978189 | 0.83 | HSD17B1 (0.70) | HSD17B1ESR1ESR2LMNASHBG | |
| SCHEMBL23711105 | 0.82 | HSD17B1 (0.72) | HSD17B1ESR1ESR2LMNASHBG | |
| SCHEMBL10080229 | 0.82 | HSD17B1 (0.72) | HSD17B1AKR1C3ESR1ESR2LMNA | |
| SCHEMBL21631888 | 0.82 | HSD17B1 (0.72) | HSD17B1ESR1ESR2LMNASHBG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003783-B2 | Steroid 17 beta -hydroxysteroid dehydrogenase inhibitors substituted with one or more oxime groups, especially aromatase inhibitors used in the treatment of endocrine-dependent tumors, especially breast cancer | STERIX LIMITED (GB) | 2011-08-23 | — | — | US | disclosed |
| US-20060074060-A1 | Compound | STERIX LIMITED (GB) | 2006-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060074060-A1 | Compound | HAT1, CBR3, ADH5 | HSD17B1 687/4885AKR1C3 5/4885ESR1 2958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.