Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ACP1 | P24666 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31553220 | 1.00 | CLK4 (0.47) | CLK4DYRK1AMAPK13RAF1MAPK9 | |
| SCHEMBL22919333 | 0.78 | PDGFRB (0.48) | CLK4DYRK1AMAPK13RAF1MAPK9 | |
| SCHEMBL5223669 | 0.73 | CLK4 (0.54) | CLK4HIF1ATP53MAPK1CYP1A2 | |
| SCHEMBL27053625 | 0.73 | CCNC (0.46) | CLK4DYRK1AGAAHIF1ATP53 | |
| SCHEMBL27730117 | 0.72 | HPGDS (0.54) | CLK4DYRK1AGAAHIF1ATP53 | |
| SCHEMBL22919303 | 0.71 | MAPT (0.51) | GAAHIF1ATP53MAPK1HSD17B10 | |
| SCHEMBL20950754 | 0.69 | CLK4 (0.50) | CLK4DYRK1APTGDRMEN1KMT2A | |
| SCHEMBL14330643 | 0.69 | CLK4 (0.56) | CLK4DYRK1AACP1KMT2AMAPT | |
| SCHEMBL20489500 | 0.69 | MAPT (0.57) | CLK4DYRK1AGAALMNAMEN1 | |
| SCHEMBL2308761 | 0.68 | NPC1 (0.68) | CLK4DYRK1AGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269720-A | acetyl-CoA synthetase short chains2(ACSS2) Small molecule inhibitors of | 库拉德夫制药私人有限公司 | 2022-04-01 | — | — | CN | disclosed |
| WO-2021014415-A2 | SMALL MOLECULE INHIBITORS OF ACETYL COENZYME A SYNTHETASE SHORT CHAIN 2 (ACSS2) | CURADEV PHARMA PVT. LTD. (IN) | 2021-01-28 | — | — | WO | disclosed |