Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ACP1 | P24666 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17640679 | 0.78 | NPC1 (0.49) | CLK4MAPTNPC1RAB9AMEN1 | |
| SCHEMBL17640680 | 0.77 | PIK3CD (0.51) | CLK4MAPTNPC1RAB9AMEN1 | |
| SCHEMBL28681917 | 0.75 | HPGD (0.74) | MAPTMEN1KMT2AHPGDACP1 | |
| SCHEMBL5227004 | 0.75 | NPC1 (0.62) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL19307654 | 0.73 | PIK3CD (0.49) | CLK4MAPTNPC1RAB9AMEN1 | |
| SCHEMBL17640655 | 0.73 | HIF1A (0.44) | CLK4MAPTNPC1RAB9AMEN1 | |
| SCHEMBL22919409 | 0.73 | CLK4 (0.47) | CLK4MAPTMEN1KMT2AHPGD | |
| SCHEMBL31553220 | 0.73 | CLK4 (0.47) | CLK4MAPTMEN1KMT2AHPGD | |
| SCHEMBL5221958 | 0.72 | ALDH1A1 (0.51) | MAPTNPC1RAB9AHPGDKDM4E | |
| SCHEMBL1753019 | 0.72 | NPC1 (0.86) | CLK4MAPTNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| US-6664256-B1 | Interleukin- 1 beta inhibitors | KOWA CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| EP-1300399-A1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |