SCHEMBL22919736

SCHEMBL22919736

CCCCCc1ccc(C(=O)Nc2ccc3c(c2)nc(N)n3CCCc2ccccc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ EHMT2 Q96KQ7 2/20 0.56
▸ EHMT1 Q9H9B1 1/20 0.56
▸ TRPV1 Q8NER1 10/20 0.52
▸ MAPT P10636 2/20 0.48
▸ TP53 P04637 2/20 0.47
▸ KDM4E B2RXH2 1/20 0.47
▸ MEN1 O00255 1/20 0.47
▸ USP2 O75604 1/20 0.47
▸ LMNA P02545 1/20 0.47
▸ TSHR P16473 1/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ NPSR1 Q6W5P4 1/20 0.47
▸ HSD17B10 Q99714 1/20 0.47
▸ CNR2 P34972 1/20 0.47
▸ TLR8 Q9NR97 2/20 0.47
▸ MCHR1 Q99705 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL21437255 0.98 EHMT2 (0.55) EHMT2EHMT1TRPV1MAPTTLR8
Hydrochloric Acid SCHEMBL21437413 0.98 EHMT2 (0.55) EHMT2EHMT1TRPV1MAPTTLR8
Hydrochloric Acid SCHEMBL21437363 0.98 EHMT2 (0.55) EHMT2EHMT1TRPV1MAPTTLR8
Hydrochloric Acid SCHEMBL21437349 0.97 EHMT2 (0.53) EHMT2EHMT1TRPV1MAPTTP53
Hydrochloric Acid SCHEMBL28512158 0.96 EHMT2 (0.56) EHMT2EHMT1TRPV1MAPTTP53
Hydrochloric Acid SCHEMBL21437123 0.95 TRPV1 (0.52) EHMT2EHMT1TRPV1MAPTTP53
Hydrochloric Acid SCHEMBL21437074 0.94 EHMT2 (0.56) EHMT2EHMT1TRPV1MAPTTP53
SCHEMBL22919735 0.94 TRPV1 (0.51) EHMT2EHMT1TRPV1MAPTTP53
Hydrochloric Acid SCHEMBL21437126 0.93 TRPV1 (0.50) EHMT2EHMT1TRPV1MAPTTP53
Hydrochloric Acid SCHEMBL21437409 0.93 TRPV1 (0.52) EHMT2EHMT1TRPV1MAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230138583-A1 SUBSTITUTED 2-AMINOBENZIMIDAZOLES ANALOGS AS ANTIBIOFILM AGENTS OHIO STATE INNOVATION FOUNDATION 2023-05-04 — — US disclosed
US-20230138583-A1 SUBSTITUTED 2-AMINOBENZIMIDAZOLES ANALOGS AS ANTIBIOFILM AGENTS OHIO STATE INNOVATION FOUNDATION 2023-05-04 — — US disclosed
US-20210023060-A1 SUBSTITUTED 2-AMINOBENZIMIDAZOLES ANALOGS AS ANTIBIOFILM AGENTS NORTH CAROLINA STATE UNIVERSITY 2021-01-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210023060-A1 SUBSTITUTED 2-AMINOBENZIMIDAZOLES ANALOGS AS ANTIBIOFILM AGENTS ITGB3, ITGB2, ITGAM EHMT2 1620/4885EHMT1 2401/4885TRPV1 1481/4885
US-20230138583-A1 SUBSTITUTED 2-AMINOBENZIMIDAZOLES ANALOGS AS ANTIBIOFILM AGENTS ITGB3, ITGB2, ITGAM EHMT2 1620/4885EHMT1 2401/4885TRPV1 1481/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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