ITGAM — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL46558	1.00	7/20
SCHEMBL46561	1.00	7/20
SCHEMBL684267	0.82	7/20
SCHEMBL5142920	0.79	7/20
SCHEMBL5142921	0.79	7/20
SCHEMBL46549	0.63	7/20
SCHEMBL46465	1.00	6/20
SCHEMBL683059	1.00	6/20
SCHEMBL684265	1.00	6/20
SCHEMBL46217	0.80	6/20
SCHEMBL684060	0.80	6/20
SCHEMBL5167082	0.77	6/20
SCHEMBL5167090	0.77	6/20
SCHEMBL5145053	0.74	6/20
SCHEMBL5145055	0.74	6/20
SCHEMBL46469	0.74	6/20
SCHEMBL46467	0.74	6/20
SCHEMBL5147227	0.73	6/20
SCHEMBL5147232	0.73	6/20
SCHEMBL5166105	0.68	6/20

Clinical trials — most relevant to ITGAM by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Monoclonal Antibody Therapy in Treating Patients With Advanced Colorectal Cancer	PHASE1/PHASE2	COMPLETED
68 Ga-NODAGA-E[c(RGDγK)]2: Positron Emission Tomography Tracer for Imaging of Angiogenesis in Ischemic Heart Disease	PHASE2	UNKNOWN
A Gene Therapy Trial to Evaluate the Safety and Efficacy of RP-L201 in Subjects With Leukocyte Adhesion Deficiency-I	PHASE1	WITHDRAWN
Cigarette Smoke Nasal and Whole Blood Challenge in Patients With Chronic Obstructive Pulmonary Disease (COPD)	PHASE1	COMPLETED
Vedolizumab (Anti-alpha4beta7) in Subjects With HIV Infection Undergoing Analytical Treatment Interruption	PHASE1	COMPLETED
Molecularly Targeted Radionuclide Therapy Via the Integrin Alphavbeta6	PHASE1	RECRUITING
Safety/Biomarker Study of CNTO 95 and Avastin in Solid Tumors	PHASE1	COMPLETED
68Ga-BNOTA-PRGD2 PET/CT in Patients With Rheumatoid Arthritis	EARLY_PHASE1	UNKNOWN
68Ga-NOTA-PRGD2 PET/CT in Patients With Lung Injury and Pulmonary Fibrosis	EARLY_PHASE1	UNKNOWN
68Ga-BNOTA-PRGD2 PET/CT in Evaluation of Stroke	EARLY_PHASE1	UNKNOWN
68Ga-BNOTA-PRGD2 PET/CT in Diagnosis and Evaluation of Glioma	EARLY_PHASE1	UNKNOWN
68Ga-BNOTA-PRGD2 PET/CT in Healthy Volunteers and Lung Cancer Patients	EARLY_PHASE1	UNKNOWN
Safety and Efficacy of ONT01 in Lupus	EARLY_PHASE1	RECRUITING
99mTc-3PRGD2 SPECT/CT in Rheumatoid Arthritis Patients	EARLY_PHASE1	COMPLETED
Angiogenesis and Fibrosis in Aortic Stenosis	nan	COMPLETED
Angiogenesis and Fibrosis in Myocardial Infarction	nan	COMPLETED
Anti-αIIbβ3 Immunization in Glanzmann Thrombasthenia: Prevalence and Associated Risk Factors: Thrombasthenia Anti-αIIbβ3 Antibodies Study (TAAS)	nan	COMPLETED
Role of CD11a in Pathogenesis of Primary ITP and Effect of Immunosuppressive Therapy on Its Level	nan	COMPLETED
The Role of CD4+ T Cell Subsets in the Mechanism of Action of Vedolizumab in Ulcerative Colitis	nan	UNKNOWN
CancerenD24 Screening as an Aid to the Clinician for the Diagnosis of Cancer	nan	RECRUITING
Clinical Study of 18F-FAPI-RGD in Ovarian Cancer	nan	COMPLETED
IMaging Pilot Study of the αvβ6 Integrin Radiotracer [18F]-A20FMDV2 in PAtients With Solid Cancer Types	nan	COMPLETED
Cd11b and Cd56 as Prognostic Markers in Acute Myeloid Leukemia	nan	UNKNOWN
The Role of Platelet Surface α2β1 Integrin Expression as a Risk Factor in Thrombotic and/or Bleeding Complications	nan	COMPLETED
Potential Role of microRNA 410 and BIRC7 Pathways in Recurrent Spontaneous Miscarriage	nan	COMPLETED
ITGA2b and SELP Expression in Cancer Pancreas and Biliary Tract Cancer	nan	UNKNOWN
T Lymphocyte Subsets in Ulcerative Colitis	nan	NOT_YET_RECRUITING
Clinical Pattern of Glanzemnn Thrombathenia in Children Attending Assiut University Children Hospital	nan	NOT_YET_RECRUITING
Eosinophil β1 Integrin Activation as a Biomarker for Eosinophilic Esophagitis	nan	COMPLETED
The Role of the Novel 99mTc-NC100692 Tracer in Patients at High Risk or Known Breast Cancer	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a ITGAM binder may also engage these)

Protein	Name	Similarity
Q3V0T4	—	1.000	Q3V0T4 →
P05555	—	1.000	P05555 →
Q13349	—	1.000	Q13349 →
Q9QXH4	—	0.998	Q9QXH4 →
ITGAL	Integrin alpha-L	0.998	landscape →
P20702	—	0.997	P20702 →
P38570	—	0.997	P38570 →
Q62469	—	0.996	Q62469 →
Q9QYE7	—	0.996	Q9QYE7 →
P24063	—	0.992	P24063 →
P61625	—	0.991	P61625 →
O75578	—	0.990	O75578 →
P61622	—	0.989	P61622 →
E1BFX5	—	0.987	E1BFX5 →
ITGA2	Integrin alpha-2	0.986	landscape →
Q60677	—	0.985	Q60677 →
Q9UKX5	—	0.985	Q9UKX5 →
Q62470	—	0.984	Q62470 →
P11688	—	0.984	P11688 →
P26006	—	0.983	P26006 →
P53710	—	0.983	P53710 →
F1MMS9	—	0.982	F1MMS9 →
B8JK39	—	0.981	B8JK39 →
Q13797	—	0.980	Q13797 →
ITGA5	Integrin alpha-5	0.980	landscape →
ITGA2B	Integrin alpha-IIb	0.980	landscape →
Q13683	—	0.979	Q13683 →
P17852	—	0.977	P17852 →
ITGA8	Integrin alpha-8 [Cleaved into: Integrin alph	0.977	landscape →
Q63258	—	0.975	Q63258 →