Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 1/20 | 0.42 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22920035 | 0.81 | MAOA (0.47) | USP1WDR48KDM4EKMT2AL3MBTL1 | |
| SCHEMBL11511834 | 0.80 | USP1 (0.48) | USP1WDR48DGAT1KMT2AL3MBTL1 | |
| SCHEMBL22919961 | 0.79 | HRH3 (0.44) | KDM4EKMT2AL3MBTL1HTTTDP1 | |
| SCHEMBL22920027 | 0.78 | NPC1 (0.41) | KDM4EKMT2AL3MBTL1HTTTDP1 | |
| SCHEMBL20400977 | 0.77 | STAT3 (0.52) | KDM4EKMT2AL3MBTL1HTTTDP1 | |
| SCHEMBL20418716 | 0.75 | USP1 (0.35) | USP1WDR48KDM4EKMT2AL3MBTL1 | |
| SCHEMBL20401100 | 0.75 | STAT3 (0.43) | KMT2ATDP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL20401141 | 0.75 | STAT3 (0.42) | USP1WDR48KDM4EKMT2AL3MBTL1 | |
| SCHEMBL29447666 | 0.74 | USP1 (0.37) | USP1WDR48KDM4EL3MBTL1NPC1 | |
| SCHEMBL20400421 | 0.74 | STAT3 (0.41) | KDM4EKMT2AL3MBTL1HTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021016333-A1 | ARYL SULFONAMIDES AS SMALL MOLECULE STAT3 INHIBITORS | UNIVERSITY OF HAWAII (US) | 2021-01-28 | — | — | WO | disclosed |