Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | FES | P07332 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | ROS1 | P08922 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.44 |
| ▸ | FER | P16591 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | MARK3 | P27448 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22922569 | 1.00 | PLK4 (0.44) | PLK4AURKAJAK2ROCK2PRKD3 | |
| SCHEMBL22922402 | 1.00 | PLK4 (0.44) | PLK4AURKAJAK2ROCK2PRKD3 | |
| SCHEMBL21593049 | 0.80 | MAP4K1 (0.57) | MAP4K1DYRK1BMAP3K11TNIK | |
| SCHEMBL22922400 | 0.79 | DYRK1A (0.60) | PLK4AURKAJAK2ROCK2PRKD3 | |
| SCHEMBL28591609 | 0.79 | MAP4K1 (0.55) | MAP4K1MAP3K11CYP11B2TNIK | |
| SCHEMBL28591607 | 0.79 | MAP4K1 (0.55) | MAP4K1MAP3K11CYP11B2TNIK | |
| SCHEMBL28597585 | 0.79 | MAP4K1 (0.55) | MAP4K1MAP3K11CYP11B2TNIK | |
| SCHEMBL26146100 | 0.78 | MAP4K1 (0.48) | MAP4K1SGK1DYRK1BCAMKK2AXL | |
| SCHEMBL22922565 | 0.78 | MAP4K1 (0.56) | MAP4K1DYRK1BMAP3K11TNIK | |
| SCHEMBL22922550 | 0.78 | MAP4K1 (0.53) | PLK4AURKAJAK2ROCK2PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112239473-B | Process for preparing tricyclic compounds as HPK1 inhibitors | 百济神州(北京)生物科技有限公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-114127067-A | Tricyclic compounds as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-03-01 | — | — | CN | disclosed |
| WO-2021013083-A1 | TRICYCLIC COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-28 | — | — | WO | disclosed |
| CN-112239473-A | Tricyclic compounds as HPK1 inhibitors | 百济神州(北京)生物科技有限公司 | 2021-01-19 | — | — | CN | disclosed |