Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 9/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.47 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.47 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3614598 | 1.00 | DNM1 (0.68) | DNM1ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL8309033 | 1.00 | DNM1 (0.68) | DNM1ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL22923343 | 1.00 | DNM1 (0.68) | DNM1ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL21891269 | 1.00 | DNM1 (0.68) | DNM1ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL24522348 | 1.00 | DNM1 (0.68) | DNM1ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL22618484 | 1.00 | DNM1 (0.68) | DNM1ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL24294234 | 1.00 | DNM1 (0.68) | DNM1ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL21984825 | 1.00 | DNM1 (0.68) | DNM1ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL24969585 | 1.00 | DNM1 (0.68) | DNM1ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL9501455 | 1.00 | DNM1 (0.68) | DNM1ALDH1A1MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11273149-B2 | Compositions and methods for the treatment of amyotrophic lateral sclerosis, Parkinson's disease, Parkinson's disease with dementia, dementia with Lewy bodies, and multiple system atrophy | STEALTH BIOTHERAPEUTICS INC. (US) | 2022-03-15 | — | — | US | disclosed |
| US-20210023062-A1 | Compositions and Methods for the Treatment of Amyotrophic Lateral Sclerosis, Parkinson's Disease, Parkinson's Disease with Dementia, Dementia with Lewy Bodies, and Multiple System Atrophy | STEALTH BIOTHERAPEUTICS INC. | 2021-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11273149-B2 | Compositions and methods for the treatment of amyotrophic lateral sclerosis, Parkinson's disease, Parkinson's disease with dementia, dementia with Lewy bodies, and multiple system atrophy | NLN, TARDBP, PARK7 | DNM1 57/4885ALDH1A1 4559/4885MEN1 4548/4885 |
| US-20210023062-A1 | Compositions and Methods for the Treatment of Amyotrophic Lateral Sclerosis, Parkinson's Disease, Parkinson's Disease with Dementia, Dementia with Lewy Bodies, and Multiple System Atrophy | NLN, TARDBP, PARK7 | DNM1 57/4885ALDH1A1 4559/4885MEN1 4548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.