Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 4/20 | 0.40 |
| ▸ | CTSK | P43235 | 4/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8366813 | 0.83 | CA1 (0.49) | MEN1GAAKMT2ATDP1CA1 | |
| SCHEMBL9600202 | 0.81 | MEN1 (0.46) | MEN1GAAKMT2ATDP1CA1 | |
| SCHEMBL1457816 | 0.81 | MEN1 (0.46) | MEN1GAAKMT2ATDP1CA1 | |
| SCHEMBL556588 | 0.81 | MEN1 (0.46) | MEN1GAAKMT2ATDP1CA1 | |
| SCHEMBL9054160 | 0.81 | KMT2A (0.46) | MEN1GAAKMT2ATDP1CA1 | |
| SCHEMBL17177660 | 0.81 | MEN1 (0.46) | MEN1GAAKMT2ATDP1CA1 | |
| SCHEMBL20367073 | 0.80 | CTSK (0.50) | MEN1GAAKMT2ATDP1CA1 | |
| SCHEMBL20355676 | 0.80 | MEN1 (0.45) | MEN1GAAKMT2ATDP1CA1 | |
| SCHEMBL18290278 | 0.79 | MEN1 (0.47) | MEN1GAAKMT2ATDP1CA1 | |
| SCHEMBL1105702 | 0.79 | PCSK9 (0.50) | MEN1GAAKMT2ATDP1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021016413-A1 | SYNTHESIS OF BICYCLIC INHIBITORS OF HISTONE DEACETYLASE | ALKERMES, INC. (US) | 2021-01-28 | — | — | WO | disclosed |