Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.35 |
| ▸ | FLT1 | P17948 | 3/20 | 0.35 |
| ▸ | FLT4 | P35916 | 3/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.32 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | BPTF | Q12830 | 1/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22925604 | 0.86 | KDR (0.35) | KDRFLT1FLT4IMPDH2GRM5 | |
| SCHEMBL29620869 | 0.83 | NPSR1 (0.39) | KDRFLT1FLT4RAB9AKDM4E | |
| SCHEMBL24636937 | 0.83 | NPSR1 (0.39) | KDRFLT1FLT4RAB9AKDM4E | |
| SCHEMBL22925785 | 0.77 | KDR (0.40) | KDRFLT1FLT4CCR1CCR5 | |
| SCHEMBL22925712 | 0.76 | ALOX5 (0.47) | KDRFLT1FLT4IMPDH2RAB9A | |
| SCHEMBL22925780 | 0.75 | CCR1 (0.32) | KDRFLT1FLT4CCR1CCR5 | |
| SCHEMBL22926082 | 0.73 | TRPV1 (0.47) | KDRFLT1FLT4IMPDH2 | |
| SCHEMBL29621019 | 0.73 | KDR (0.39) | KDRFLT1FLT4IMPDH2 | |
| SCHEMBL22925562 | 0.73 | KDR (0.39) | KDRFLT1FLT4IMPDH2 | |
| SCHEMBL22925966 | 0.70 | CHEK1 (0.41) | KDRFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021012018-A1 | INHIBITOR COMPOUNDS | Cincera Therapeutics Pty Ltd (AU) | 2021-01-28 | — | — | WO | disclosed |