Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MGLL | Q99685 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16151156 | 0.83 | HRH3 (0.58) | HRH3ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL21555271 | 0.83 | FASN (0.45) | HRH3ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL19888051 | 0.82 | MEN1 (0.53) | ALDH1A1HPGDMEN1KMT2AHTT | |
| SCHEMBL16150199 | 0.79 | HRH3 (0.62) | HRH3KCNH2ALDH1A1HPGDMEN1 | |
| SCHEMBL19888173 | 0.78 | MGLL (0.40) | MEN1KMT2AMGLLMAPK1 | |
| Hydrochloric Acid SCHEMBL16151108 | 0.78 | HRH3 (0.61) | HRH3KCNH2ALDH1A1HPGDMEN1 | |
| SCHEMBL16149777 | 0.76 | HRH3 (0.57) | HRH3KCNH2ALDH1A1HPGDMEN1 | |
| SCHEMBL4941766 | 0.76 | HRH3 (0.61) | HRH3KCNH2ALDH1A1HPGDMGLL | |
| SCHEMBL19888123 | 0.75 | HRH3 (0.56) | HRH3KCNH2MEN1KMT2AMGLL | |
| SCHEMBL22536662 | 0.74 | FASN (0.63) | ALDH1A1HPGDMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3587406-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2021-01-27 | — | — | EP | disclosed |