Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16150199 | 0.82 | HRH3 (0.62) | HRH3MAPK1HTTKCNH2HSD17B10 | |
| Hydrochloric Acid SCHEMBL16151108 | 0.81 | HRH3 (0.61) | HRH3MAPK1HTTKCNH2HSD17B10 | |
| SCHEMBL12655843 | 0.80 | HRH3 (0.74) | HRH3KCNH2MGLL | |
| SCHEMBL4557128 | 0.79 | HRH3 (0.73) | HRH3KCNH2MGLL | |
| SCHEMBL4557131 | 0.79 | HRH3 (0.73) | HRH3KCNH2MGLL | |
| SCHEMBL16151156 | 0.79 | HRH3 (0.58) | HRH3MGLLALDH1A1HPGD | |
| SCHEMBL16149777 | 0.78 | HRH3 (0.57) | HRH3MAPK1HTTKCNH2MGLL | |
| SCHEMBL1812862 | 0.77 | HRH3 (0.71) | HRH3KCNH2 | |
| SCHEMBL3667518 | 0.77 | HSD17B10 (0.72) | HRH3MAPK1HTTKCNH2HSD17B10 | |
| SCHEMBL18355573 | 0.77 | MAPK1 (0.66) | HRH3MAPK1HTTKCNH2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119458-A1 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119458-A1 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | HNMT, HRH4, HRH3 | HRH3 3/4885MAPK1 2641/4885HTT 378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.