Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 9/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 4/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28716544 | 1.00 | HPGDS (0.40) | HPGDSSLC6A2SLC6A4GPR139MGLL | |
| SCHEMBL28716543 | 1.00 | HPGDS (0.40) | HPGDSSLC6A2SLC6A4GPR139MGLL | |
| SCHEMBL1500619 | 0.90 | CNR1 (0.43) | CNR1S1PR3CNR2 | |
| SCHEMBL1500617 | 0.90 | CNR1 (0.43) | CNR1S1PR3CNR2 | |
| SCHEMBL17064579 | 0.84 | ALDH1A1 (0.36) | HPGDSALDH1A1TSHRLMNAMAPT | |
| SCHEMBL17064581 | 0.84 | ALDH1A1 (0.36) | HPGDSALDH1A1TSHRLMNAMAPT | |
| SCHEMBL17064583 | 0.84 | ALDH1A1 (0.36) | HPGDSALDH1A1TSHRLMNAMAPT | |
| SCHEMBL24682843 | 0.83 | CNR1 (0.38) | GPR139CNR1ALDH1A1CNR2 | |
| SCHEMBL11025676 | 0.83 | CNR1 (0.38) | GPR139CNR1ALDH1A1CNR2 | |
| SCHEMBL11891925 | 0.83 | CNR1 (0.38) | GPR139CNR1ALDH1A1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021016317-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2021-01-28 | — | — | WO | disclosed |