Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30784777 | 0.83 | GAA (0.46) | GAAP2RX7ADRB2ADRB1AOC3 | |
| SCHEMBL22927660 | 0.79 | IDO1 (0.39) | P2RX7AOC3CYP2D6NFKB1HIF1A | |
| SCHEMBL4184665 | 0.79 | SLC6A2 (0.43) | GAAADRB2ADRB1AOC3CYP2D6 | |
| SCHEMBL3061790 | 0.79 | GAA (0.44) | GAAADRB2ADRB1AOC3CYP2D6 | |
| SCHEMBL20281128 | 0.78 | OPRM1 (0.39) | GAAADRB2ADRB1AOC3CYP2D6 | |
| SCHEMBL29844926 | 0.78 | OPRM1 (0.39) | GAAADRB2ADRB1AOC3CYP2D6 | |
| SCHEMBL7046535 | 0.78 | TSHR (0.41) | GAANFKB1HIF1ACYP2C19HDAC4 | |
| SCHEMBL29609159 | 0.75 | ACP3 (0.53) | ADRB2ADRB1AOC3CYP2D6NFKB1 | |
| SCHEMBL477580 | 0.75 | ACP3 (0.53) | ADRB2ADRB1AOC3CYP2D6NFKB1 | |
| SCHEMBL477602 | 0.75 | ACP3 (0.53) | ADRB2ADRB1AOC3CYP2D6NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240246946-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. | 2024-07-25 | — | — | US | disclosed |
| EP-4330254-A1 | MODULATORS OF TREX1 | Constellation Pharmaceuticals, Inc. (US) | 2024-03-06 | — | — | EP | disclosed |
| CN-117545754-A | Modulators of TREX1 | 星座制药公司 | 2024-02-09 | — | — | CN | disclosed |
| WO-2022232004-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2022-11-03 | — | — | WO | disclosed |
| US-20220289728-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS INC (US) | 2022-09-15 | — | — | US | disclosed |
| EP-4003985-A1 | MODULATORS OF TREX1 | Constellation Pharmaceuticals, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |
| CN-114174290-A | Modulators of TREX1 | 星座制药公司 | 2022-03-11 | — | — | CN | disclosed |
| WO-2021016317-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2021-01-28 | — | — | WO | disclosed |
| WO-2021016317-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2021-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220289728-A1 | MODULATORS OF TREX1 | CFTR, SLC10A1, CYP27A1 | GAA 129/4885P2RX7 114/4885ADRB2 2819/4885 |
| US-20240246946-A1 | MODULATORS OF TREX1 | CFTR, SLC10A1, CYP27A1 | GAA 129/4885P2RX7 114/4885ADRB2 2819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.