Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.59 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL804182 | 0.87 | TDP1 (0.63) | TDP1MAPTSMN1; SMN2LIN28AKCNA5 | |
| SCHEMBL2323126 | 0.86 | TDP1 (0.57) | TDP1MAPTSMN1; SMN2LIN28AKCNA5 | |
| Hydrochloric Acid SCHEMBL28308406 | 0.85 | TDP1 (0.61) | TDP1MAPTSMN1; SMN2LIN28AKCNA5 | |
| SCHEMBL996544 | 0.83 | TDP1 (0.64) | TDP1MAPTSMN1; SMN2LIN28AKCNA5 | |
| SCHEMBL210394 | 0.83 | TDP1 (0.63) | TDP1MAPTSMN1; SMN2LIN28AKCNA5 | |
| SCHEMBL29894985 | 0.83 | TDP1 (0.63) | TDP1MAPTSMN1; SMN2LIN28AKCNA5 | |
| SCHEMBL3600311 | 0.82 | KDM4E (0.58) | TDP1MAPTSMN1; SMN2LIN28AKCNA5 | |
| SCHEMBL18301478 | 0.80 | TDP1 (0.55) | TDP1MAPTSMN1; SMN2LIN28AKCNA5 | |
| SCHEMBL6051881 | 0.80 | TDP1 (0.60) | TDP1MAPTSMN1; SMN2LIN28AKCNA5 | |
| SCHEMBL12245197 | 0.80 | TDP1 (0.55) | TDP1MAPTSMN1; SMN2LIN28AKCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3888658-A1 | EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO | Effector Therapeutics Inc. (US) | 2021-10-06 | — | — | EP | disclosed |
| EP-3380101-B1 | EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO | EFFECTOR THERAPEUTICS INC (US) | 2021-01-27 | — | — | EP | disclosed |