Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | BDKRB2 | P30411 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22930105 | 1.00 | LMNA (0.49) | LMNACYP1A2CYP2D6CYP2C19CSNK1E | |
| SCHEMBL19350974 | 0.98 | LMNA (0.47) | LMNACYP1A2CYP2D6CYP2C19CSNK1E | |
| Hydrochloric Acid SCHEMBL391948 | 0.89 | LMNA (0.46) | LMNACYP1A2CYP2D6CYP2C19CSNK1E | |
| SCHEMBL1498212 | 0.85 | CYP1A2 (0.42) | LMNACYP1A2CYP2D6CYP2C19BDKRB2 | |
| SCHEMBL22930104 | 0.84 | LMNA (0.47) | LMNACYP1A2CYP2D6CYP2C19NPC1 | |
| SCHEMBL22930106 | 0.84 | LMNA (0.47) | LMNACYP1A2CYP2D6CYP2C19NPC1 | |
| SCHEMBL19350979 | 0.84 | LMNA (0.47) | LMNACYP1A2CYP2D6CYP2C19NPC1 | |
| SCHEMBL28265214 | 0.84 | LMNA (0.47) | LMNACYP1A2CYP2D6CYP2C19CSNK1E | |
| SCHEMBL19350978 | 0.84 | LMNA (0.47) | LMNACYP1A2CYP2D6CYP2C19CSNK1E | |
| SCHEMBL15736896 | 0.82 | BDKRB2 (0.52) | CSNK1EBDKRB2MMEESR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10905769-B2 | Peptide and peptide mimetic binding antagonists of polo-like kinase 1 polo box domain and methods of use | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2021-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10905769-B2 | Peptide and peptide mimetic binding antagonists of polo-like kinase 1 polo box domain and methods of use | PLK1, POLR1E, POLK | LMNA 3095/4885CYP1A2 4883/4885CYP2D6 4706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.