Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22932013 | 1.00 | THRB (0.37) | THRBPOLBADRB2KDM4EL3MBTL1 | |
| SCHEMBL22940318 | 0.88 | KDM4E (0.35) | THRBPOLBADRB2KDM4EL3MBTL1 | |
| SCHEMBL19750604 | 0.86 | KDM4E (0.38) | THRBPOLBADRB2KDM4EL3MBTL1 | |
| SCHEMBL18030861 | 0.85 | KDM4E (0.34) | THRBPOLBADRB2KDM4EL3MBTL1 | |
| SCHEMBL26968829 | 0.82 | THRB (0.53) | THRBALDH1A1LMNA | |
| SCHEMBL13113556 | 0.81 | POLB (0.46) | POLBADRB2KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL10304880 | 0.77 | — | — | |
| SCHEMBL3248428 | 0.77 | — | — | |
| SCHEMBL10304890 | 0.77 | — | — | |
| SCHEMBL13154507 | 0.77 | L3MBTL1 (0.33) | POLBADRB2KDM4EL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021018857-A1 | 3,6-DIAMINO-PYRIDAZIN-3-YL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS | LES LABORATOIRES SERVIER (FR) | 2021-02-04 | — | — | WO | disclosed |
| WO-2021018858-A1 | 6,7-DIHYDRO-5H-PYRIDO[2,3-C]PYRIDAZINE DERIVATIVES AND RELATED COMPOUNDS AS BCL-XL PROTEIN INHIBITORS AND PRO-APOPTOTIC AGENTS FOR TREATING CANCER | LES LABORATOIRES SERVIER (FR) | 2021-02-04 | — | — | WO | disclosed |