Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 17/20 | 0.53 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28722935 | 0.84 | CD38 (0.77) | CD38 | |
| SCHEMBL22933151 | 0.84 | CD38 (0.77) | CD38 | |
| SCHEMBL22933157 | 0.82 | CD38 (0.55) | CD38IRAK4 | |
| SCHEMBL22936248 | 0.82 | CD38 (0.71) | CD38 | |
| SCHEMBL31484704 | 0.78 | CHEK1 (0.43) | CD38 | |
| SCHEMBL23329529 | 0.78 | CD38 (0.56) | CD38IRAK4 | |
| SCHEMBL23304751 | 0.78 | CD38 (0.85) | CD38 | |
| SCHEMBL23329143 | 0.77 | CD38 (0.72) | CD38 | |
| SCHEMBL23329185 | 0.76 | CD38 (0.86) | CD38 | |
| SCHEMBL23329326 | 0.74 | CD38 (0.86) | CD38 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021021986-A1 | HETEROBICYCLIC AMIDES AS INHIBITORS OF CD38 | RIBON THERAPEUTICS, INC. (US) | 2021-02-04 | — | — | WO | disclosed |