Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CHKA | P35790 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | ESRRB | O95718 | 2/20 | 0.47 |
| ▸ | ESRRG | P62508 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL81814 | 0.94 | MAPT (0.65) | MAPTKDM4EALDH1A1KMT2AADRA2C | |
| SCHEMBL15489560 | 0.94 | MAPT (0.65) | MAPTKDM4EALDH1A1KMT2AADRA2C | |
| SCHEMBL82022 | 0.86 | CHKA (0.64) | MAPTKDM4EALDH1A1KMT2AADRA2C | |
| SCHEMBL7105773 | 0.84 | ADRB1 (0.70) | MAPTKDM4EALDH1A1KMT2AADRA2C | |
| SCHEMBL3414344 | 0.84 | ADRB1 (0.70) | MAPTKDM4EALDH1A1KMT2AADRA2C | |
| SCHEMBL10063748 | 0.84 | ADRB1 (0.70) | MAPTKDM4EALDH1A1KMT2AADRA2C | |
| SCHEMBL20231203 | 0.84 | MAPT (0.63) | MAPTKDM4EALDH1A1KMT2AADRA2C | |
| SCHEMBL24921279 | 0.81 | NPC1 (0.54) | MAPTKDM4EALDH1A1KMT2AADRA2C | |
| SCHEMBL22542025 | 0.81 | ADRB1 (0.55) | MAPTKDM4EALDH1A1KMT2AADRA2C | |
| SCHEMBL14372238 | 0.80 | AKR1C3 (0.73) | MAPTALDH1A1GAAGFERNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021180103-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2021-09-16 | — | — | WO | disclosed |
| WO-2021018018-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INIDBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2021-02-04 | — | — | WO | disclosed |