Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2292726 | 0.87 | MAPT (0.54) | MAPTGAACRHBPCRHR2TDP1 | |
| SCHEMBL8742131 | 0.77 | MAPT (0.54) | MAPTGAACRHBPCRHR2HTT | |
| SCHEMBL3988345 | 0.77 | MAPT (0.54) | MAPTGAACRHBPCRHR2HTT | |
| SCHEMBL16508606 | 0.75 | MAPT (0.50) | MAPTGAACRHBPCRHR2HTT | |
| SCHEMBL26187892 | 0.75 | MAPT (0.46) | MAPTGAACRHBPCRHR2HTT | |
| SCHEMBL15257085 | 0.74 | MAPT (0.53) | MAPTGAACRHBPCRHR2HTT | |
| SCHEMBL2294500 | 0.74 | KMT2A (0.47) | MAPTGAAHTTTDP1MAPK1 | |
| SCHEMBL18473647 | 0.72 | MAPT (0.48) | MAPTGAACRHBPCRHR2HTT | |
| SCHEMBL3592020 | 0.72 | MAPT (0.51) | MAPTGAACRHBPCRHR2HTT | |
| SCHEMBL13729342 | 0.71 | KMT2A (0.53) | MAPTGAAHTTTDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003806-B2 | Integrin antagonists useful as anticancer agents | OSI Pharmaceuticals, LLC (US) | 2011-08-23 | — | — | US | disclosed |