Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13729342 | 0.82 | KMT2A (0.53) | KMT2AMEN1PDK1PDK2PDK3 | |
| SCHEMBL2294455 | 0.80 | CYP2C19 (0.47) | KMT2AMEN1RAB9AGAAALDH1A1 | |
| SCHEMBL10359712 | 0.76 | MAPK1 (0.53) | KMT2AMEN1PDK1PDK2PDK3 | |
| SCHEMBL11657337 | 0.75 | PDK1 (0.54) | KMT2AMEN1PDK1PDK2PDK3 | |
| SCHEMBL5693295 | 0.75 | KMT2A (0.50) | KMT2AMEN1PDK1PDK2PDK3 | |
| SCHEMBL2294061 | 0.74 | MAPT (0.49) | KMT2AMEN1RAB9AGAAALDH1A1 | |
| SCHEMBL27306411 | 0.74 | MAPK1 (0.50) | KMT2AMEN1PDK1PDK2PDK3 | |
| SCHEMBL24187914 | 0.73 | PDK1 (0.55) | KMT2AMEN1PDK1PDK2PDK3 | |
| SCHEMBL4867823 | 0.73 | KMT2A (0.51) | KMT2AMEN1PDK1PDK2PDK3 | |
| SCHEMBL677655 | 0.72 | MAPK1 (0.55) | KMT2AMEN1PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003806-B2 | Integrin antagonists useful as anticancer agents | OSI Pharmaceuticals, LLC (US) | 2011-08-23 | — | — | US | disclosed |