Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | ATF4 | P18848 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 2/20 | 0.30 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28442285 | 1.00 | ADORA2A (0.48) | ADORA2AADORA3ADORA2BADORA1DCPS | |
| SCHEMBL1845253 | 0.87 | ADORA2A (0.46) | ADORA2AADORA3ADORA2BADORA1DCPS | |
| SCHEMBL1845258 | 0.87 | ADORA2A (0.46) | ADORA2AADORA3ADORA2BADORA1DCPS | |
| SCHEMBL20416885 | 0.86 | ADORA2A (0.46) | ADORA2AADORA3ADORA2BADORA1DCPS | |
| SCHEMBL22940755 | 0.86 | ADORA2A (0.46) | ADORA2AADORA3ADORA2BADORA1DCPS | |
| SCHEMBL18679939 | 0.86 | ADORA2A (0.48) | ADORA2AADORA3ADORA2BADORA1DCPS | |
| SCHEMBL22242037 | 0.86 | ADORA2A (0.50) | ADORA2AADORA3ADORA2BADORA1DCPS | |
| SCHEMBL536593 | 0.86 | ADORA2A (0.48) | ADORA2AADORA3ADORA2BADORA1DCPS | |
| SCHEMBL536592 | 0.86 | ADORA2A (0.48) | ADORA2AADORA3ADORA2BADORA1DCPS | |
| SCHEMBL18679940 | 0.86 | ADORA2A (0.48) | ADORA2AADORA3ADORA2BADORA1DCPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111511745-B | Pyrazolo [1,5-a ] [1, 3, 5] triazine-2-amine derivative, and preparation method and application thereof | 江苏恒瑞医药股份有限公司 | 2022-05-27 | — | — | CN | disclosed |
| US-20210355104-A1 | ADENOSINE RECEPTOR BINDING COMPOUNDS | NIKANG THERAPEUTICS, INC. (US) | 2021-11-18 | — | — | US | disclosed |
| EP-3820474-A1 | ADENOSINE RECEPTOR BINDING COMPOUNDS | Nikang Therapeutics, Inc. (US) | 2021-05-19 | — | — | EP | disclosed |
| CN-112423758-A | Adenosine receptor binding compounds | 尼康治疗公司 | 2021-02-26 | — | — | CN | disclosed |
| US-20210032253-A1 | PYRAZOLO[1,5-A][1,3,5]TRIAZINE-2-AMINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2021-02-04 | — | — | US | disclosed |
| CN-111511745-A | Pyrazolo [1,5-a ] [1,3,5] triazine-2-amine derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2020-08-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210355104-A1 | ADENOSINE RECEPTOR BINDING COMPOUNDS | ADORA2A, ADORA1, ADORA3 | ADORA2A 1/4885ADORA3 3/4885ADORA2B 4/4885 |
| US-20210032253-A1 | PYRAZOLO[1,5-A][1,3,5]TRIAZINE-2-AMINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | ADORA2A, ADORA1, ADORA2B | ADORA2A 1/4885ADORA3 5/4885ADORA2B 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.