Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 4/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.43 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29578731 | 1.00 | EPHA2 (0.43) | EPHA2P2RX3P2RX2RETERBB2 | |
| SCHEMBL22944209 | 0.83 | CHEK1 (0.48) | CHEK1CHEK2KCNH2 | |
| SCHEMBL29578206 | 0.83 | CHEK1 (0.48) | CHEK1CHEK2KCNH2 | |
| SCHEMBL22943402 | 0.82 | CHEK1 (0.48) | CHEK1CHEK2KCNH2 | |
| SCHEMBL22943432 | 0.82 | CHEK1 (0.48) | CHEK1CHEK2KCNH2 | |
| SCHEMBL29579435 | 0.82 | CHEK1 (0.48) | CHEK1CHEK2KCNH2 | |
| SCHEMBL22944636 | 0.82 | CHEK1 (0.48) | CHEK1CHEK2KCNH2 | |
| SCHEMBL22944177 | 0.81 | EPHA2 (0.43) | EPHA2P2RX3P2RX2RETERBB2 | |
| SCHEMBL29578331 | 0.81 | EPHA2 (0.43) | EPHA2P2RX3P2RX2RETERBB2 | |
| SCHEMBL22943238 | 0.81 | CHEK1 (0.47) | CHEK1CHEK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114728949-A | Heterocyclic compounds as kinase inhibitors and uses thereof | 整体生物科学私人有限公司 | 2022-07-08 | — | — | CN | disclosed |
| WO-2021019514-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITOR AND USES THEREOF | INTEGRAL BIOSCIENCES PVT. LTD. (IN) | 2021-02-04 | — | — | WO | disclosed |