Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 4/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | BUB1 | O43683 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.39 |
| ▸ | RET | P07949 | 3/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.36 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22944177 | 1.00 | EPHA2 (0.43) | EPHA2ERBB2EPHB4BUB1CHEK1 | |
| SCHEMBL22944176 | 0.82 | EPHA2 (0.48) | EPHA2ERBB2EPHB4BUB1RET | |
| SCHEMBL29578573 | 0.82 | EPHA2 (0.48) | EPHA2ERBB2EPHB4BUB1RET | |
| SCHEMBL29578731 | 0.81 | EPHA2 (0.43) | EPHA2ERBB2EPHB4CHEK1RET | |
| SCHEMBL22943803 | 0.81 | EPHA2 (0.43) | EPHA2ERBB2EPHB4CHEK1RET | |
| SCHEMBL26976889 | 0.80 | CHEK1 (0.51) | CHEK1CHEK2 | |
| SCHEMBL22944178 | 0.80 | CHEK1 (0.54) | CHEK1CHEK2 | |
| SCHEMBL29578217 | 0.79 | CHEK1 (0.52) | CHEK1RETCHEK2GPR119 | |
| SCHEMBL22943264 | 0.79 | CHEK1 (0.52) | CHEK1RETCHEK2GPR119 | |
| SCHEMBL22944209 | 0.78 | CHEK1 (0.48) | CHEK1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4007757-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITOR AND USES THEREOF | Integral Biosciences Pvt. Ltd. (IN) | 2022-06-08 | — | — | EP | disclosed |