Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22945007 | 0.80 | ALDH1A1 (0.59) | ALDH1A1RAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL21212214 | 0.79 | ALDH1A1 (0.52) | ALDH1A1RAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL22944650 | 0.77 | ALDH1A1 (0.49) | ALDH1A1RAB9AKDM4ENPC1HTT | |
| SCHEMBL21212271 | 0.76 | CBLB (0.71) | ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL21212370 | 0.76 | CBLB (0.51) | ALDH1A1RAB9AKDM4ENPC1KMT2A | |
| SCHEMBL21212315 | 0.75 | ALDH1A1 (0.52) | ALDH1A1RAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL21211819 | 0.75 | CBLB (0.66) | ALDH1A1RAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL22944651 | 0.73 | CBLB (0.71) | ALDH1A1 | |
| SCHEMBL22944920 | 0.73 | CBLB (0.71) | ALDH1A1 | |
| SCHEMBL6347118 | 0.71 | SMN1; SMN2 (0.60) | ALDH1A1RAB9AKDM4ENPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021021761-A1 | UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION | NURIX THERAPEUTICS, INC. (US) | 2021-02-04 | — | — | WO | disclosed |