Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21212214 | 0.82 | ALDH1A1 (0.52) | ALDH1A1NPC1RAB9AKDM4EPOLB | |
| SCHEMBL22945847 | 0.80 | ALDH1A1 (0.57) | ALDH1A1NPC1RAB9AKDM4EPOLB | |
| SCHEMBL11367382 | 0.79 | NPC1 (0.49) | ALDH1A1NPC1RAB9AKDM4EPOLB | |
| SCHEMBL21212315 | 0.78 | ALDH1A1 (0.52) | ALDH1A1NPC1RAB9AKDM4EPOLB | |
| SCHEMBL11511488 | 0.74 | LMNA (0.43) | ALDH1A1NPC1RAB9AKDM4EPOLB | |
| SCHEMBL22497308 | 0.74 | LMNA (0.43) | ALDH1A1NPC1RAB9AKDM4EPOLB | |
| SCHEMBL22497309 | 0.74 | LMNA (0.43) | ALDH1A1NPC1RAB9AKDM4EPOLB | |
| SCHEMBL22944664 | 0.74 | CBLB (0.55) | ALDH1A1NPC1RAB9AKDM4EPOLB | |
| SCHEMBL4197148 | 0.73 | NPC1 (0.81) | NPC1RAB9APOLBLMNAKMT2A | |
| SCHEMBL23294109 | 0.73 | POLB (0.42) | ALDH1A1NPC1RAB9AKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021021761-A1 | UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION | NURIX THERAPEUTICS, INC. (US) | 2021-02-04 | — | — | WO | disclosed |