Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | GPR34 | Q9UPC5 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20028068 | 0.83 | CAPN1 (0.48) | SCN9AALDH1A1CA2CAPN1 | |
| SCHEMBL22886539 | 0.83 | ALDH1A1 (0.42) | SCN9AGPR34ALDH1A1CA2MME | |
| SCHEMBL22886096 | 0.80 | CAPN1 (0.51) | CAPN1 | |
| SCHEMBL22886464 | 0.78 | ACE (0.42) | ALDH1A1ACEPOLB | |
| SCHEMBL20028431 | 0.75 | CAPN1 (0.53) | CAPN1 | |
| SCHEMBL21854063 | 0.75 | CAPN1 (0.53) | CAPN1 | |
| SCHEMBL20028398 | 0.75 | CAPN1 (0.45) | ALDH1A1CA2KDM4ECAPN1 | |
| SCHEMBL22886426 | 0.74 | FTO (0.42) | ALDH1A1POLBCAPN1 | |
| SCHEMBL22896350 | 0.74 | CAPN1 (0.46) | CAPN1 | |
| SCHEMBL20028391 | 0.73 | ACE (0.36) | GPR34ALDH1A1ACEPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021021816-A1 | CALPAIN INHIBITORS AND USES THEREOF FOR TREATING NEUROLOGICAL DISORDERS | BLADE THERAPEUTICS, INC. (US) | 2021-02-04 | — | — | WO | disclosed |